基本信息

姓名：肖 锋

籍贯：浙江杭州

E. mail：[email protected]

通讯地址：福建省厦门市集美大道668号，361021，综合实验大楼A901

从事合成生物学和代谢工程研究，通过改造易变假单胞菌（Pseudomonas mutabilis）、酿酒酵母（Saccharomyces cerevisiae）、毕赤酵母（Komagataella phaffii）和库德里阿兹威毕赤酵母（Pichia kudriavzevii）高效合成维生素、酚酸、糖胺聚糖和萜类等高值天然产物。

招生专业

目前课题组（陆黎明林毅课题组//faculty.manbetx88.org/~VFnQje/zh_CN/index.htm）经费充足，实验条件优越，欢迎具有生物学、生物化学、分子生物学等具有生物学背景的学生报考。

教育经历

博士：2014.09-2019.07，浙江大学化学工程与技术专业

硕士：2011.09-2014.06，浙江师范大学动物生理生态学专业

本科：2007.09-2011.06，浙江师范大学环境科学专业

工作经历

2025-03 至今，华侨大学，manbetx国际版，副研究员

2024-08 至 2025-02，华恒生物研究院，高级工程师

2022-03 至 2024-07，浙江大学博士后

2019-11 至 2022-02，浙江工业大学博士后

科研项目

主持国家自然科学基金青年基金1项，华侨大学科研启动项目1项

代表作 //orcid.org/ 0000-0003-2770-7578

(1) Xiao F, Li D, Pan Y, Lv B, Gao J, Zuo Y, Huang L, Lian J (2024) Establishing  Komagataella phaffii as a cell factory for efficient production of cholesterol sulfate ACS Sustainable Chemistry & Engineering 61, 406-415.

(2) Xiao F, Wang H, Shi Z, Huang, Q, Huang L, Lian, J^*, Cai J, and Xu Z^* (2020) Multi-level metabolic engineering of Pseudomonas mutabilis ATCC31014 for efficient production of biotin. Metabolic Engineering 61, 406-415.

(3) Xiao F, Lian J, Tu S, Xie L, Li J, Zhang F, Linhardt R, Huang H, and Zhong W^* (2022)  Metabolic engineering of Saccharomyces cerevisiae for high-level production of chlorogenic acid from glucose. ACS Synthetic Biology 11, 800-811.

(4) Lv B^#, Xiao F^#, Pan Y, Li D, L J, Dong C^*, Huang L, Xu Z, Lian J^* (2025) Establishing Komagataella phaffii as a cell factory for efficient production of chondroitin sulfate. BioDesign Research, 8(1).

(5) Jing Tian^#, Feng Xiao^#, Yezhu Xu^#, Yuen Chen, Chenli He, Su Jiang, Yunping Tang (2025) Combined metabolomics and gut microbiota analysis reveals the protective effects of α-monoglucosyl rutin against cyclophosphamide-induced intestinal injury, International Immunopharmacology, 168.

(6) Zuo Y, Xiao F, Gao J, Ye C, Jiang L, Dong C. and Lian J* (2022) Establishing Komagataella phaffii as a cell factory for efficient production of sesquiterpenoid α- santalene. Journal of Agricultural and Food Chemistry 70, 8024-8031.

(7) Gao J, Zuo Y, Xiao F, Wang Y, Li D, Xu J, Ye C, Feng L, Jiang L, Liu T, Gao D, Ma B, Huang L, Xu Z, Lian J* (2023) Biosynthesis of catharanthine in engineered Pichia pastoris. Nature Synthesis 2, 231-242.

(8) Cuifang Ye, Mengxin Li, Jucan Gao, Yimeng Zuo, Feng Xiao, Xiaojiang Jiang, Jintao Cheng, Lei Huang, Zhinan Xu, and Jiazhang Lian* (2024) Metabolic engineering of Pichia pastoris for overproduction of cis-trans nepetalactol. Metabolic Engineering 84, 83-94.

(9) Gou Y, Li D, Zhao M, Li M, Zhang J, Zhou Y, Xiao F, Liu G, Ding H, Sun C, Ye C, Dong C, Gao J, Gao D, Bao Z, Huang L, Xu Z, and Lian J* (2024) Intein-mediated temperature control for complete biosynthesis of sanguinarine and its halogenated derivatives in yeast. Nature Communications 15, 9329.

(10) Tu S, Xiao F, Mei C, Li S, Qiao P, Huang Z, He, Y, Gong Z, and Zhong W * (2023) De  novo biosynthesis of sakuranetin from glucose by engineered Saccharomyces cerevisiae. Applied Microbiology and Biotechnology 107, 3899-3909.

专利

(1) 肖锋; 王琦; 郑华宝. 适用于库德里阿兹威毕赤酵母的CRISPR/Cas9基因编辑系统及其应用，CN2025112660299.

(2) 连佳长; 肖锋. 一种发酵生产固醇类及其硫酸化衍生物和提高硫酸化度的方法，CN202411784003.9.

(3) 徐志南; 朱勇刚; 周斌; 肖锋. 一种促进生物素合成的方法、促进生物素合成的重组细胞和基因工程菌，ZL201910585879.3.

(4) 钟卫鸿；涂帅；肖锋；黄子炎；谢琳琳. 酿酒酵母产绿原酸工程菌株的构建方法及其应用，ZL202111571036.1.